In all the four boroughs for which Wyndham O’Brien sat, he was returned on the Egremont interest, in 1754 and 1761 with Government support. In the House he followed his brother who under George III adhered to their brother-in-law, George Grenville. In 1754 Wyndham O’Brien was classed as a Government supporter and remained so after Pitt and the Grenvilles had gone into opposition in the autumn of 1755. On 13 Nov. he seconded the Address
When on Pitt’s resignation in October 1761 George Grenville was pressed to assume the leadership in the Commons, ‘to give him some éclat at first’ he wished Thomond ‘might be made cofferer’
On Grenville’s dismissal Thomond immediately resigned;
He died on 21 July 1774, according to Horace Walpole ‘possessed of near £10,000 a year, and £50,000 in money’.
