Duke was defeated at Honiton in 1754, and returned in 1761 after a contest; in 1761 he also contested Ashburton. In Bute’s list he was classed as a Tory, but was sent Newcastle’s whip for the session of 1761. He appears in Fox’s list of Members favourable to the peace preliminaries, and voted with the Grenville Administration on general warrants, 6 and 18 Feb. 1764.
He died 3 Nov. 1775, aged 58.
