Drake served under Knowles in the West Indies, 1748; under Rodney in Newfoundland 1751, succeeding him as governor; under Boscawen at Lagos, 1759. At various times his career seems to have been impeded by ill-health. N. Rowe, a close friend of the Drake family, wrote about him to Sir Francis Drake in March 1750:
He’s an honest young fellow, who, though he has seen the world abroad, wants to be better acquainted with that at home. A perfect harmony between you, which I greatly wish, may be a great means thereto; I need not mention to you the obligation. His health is better than I expected, and would be more so if he’d use the means.
He retired on half pay in 1763, but in 1766 was given command of a guardship at Plymouth.
In August 1780, while holding the command in the Downs, he was offered by Sandwich employment under Rodney, but had to decline it from the ‘shattered condition of my constitution’, and for fear that ‘his Majesty’s service there might suffer from my bodily inability’.
